反応 #62993

反応方程式

pyrrolidine

2-chloroethoxyethoxyethanol

KOH

→

N-(hydroxyethoxyethoxyethyl)pyrrolidine

収率 76.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度refluxed for an additional hour
2. 2
   ろ過Filtration and distillation

実験手順

A total of 295 g of pyrrolidine and 250 g of 2-chloroethoxyethoxyethanol in 750 ml of ethanol was refluxed for 5 hours. The reaction mixture was then treated with 106 g of KOH and refluxed for an additional hour. Filtration and distillation yielded 229 g of N-(hydroxyethoxyethoxyethyl)pyrrolidine (b.p.=145° C. at 3 mm).

出典