反応 #62981

反応方程式

Bromoacetic acid

amine

2-amino-4-benzyloxyphenol

→

bromoamide

2-α-bromoacetamido-4-benzyloxyphenol

溶媒

THF

反応条件

後処理

1. 1
   ろ過After 1 hour the reaction mixture was filtered
2. 2
   その他the liquid evaporated to dryness under vacuum
3. 3
   その他The residue was crystallized from acetic acid (50 ml)

実験手順

Bromoacetic acid (13.9 g, 0.01 mole) and dicyclohexyldicarbodiimide (DCCD, 20.6 g, 0.01 mole) were added at room temperature under stirring to the amine ((b), 21.5 g, 0.01 mole) in THF (200 ml). After 1 hour the reaction mixture was filtered and the liquid evaporated to dryness under vacuum. The residue was crystallized from acetic acid (50 ml) to give the bromoamide ((c), 17 g, 50%) as white prisms. The product structure was confirmed by NMR analysis.

出典