反応 #62974

反応方程式

α-chloroacetylchloride

2-aminohydroquinone

diethanolamine

hydrochloride

→

2-(α-chloroacetamido)-hydroquinone

溶媒

acetone

water

反応条件

後処理

1. 1
   抽出extracted with ethylacetate (500 ml)
2. 2
   その他The solvent was evaporated to dryness
3. 3
   その他the solid residue (4.20 g, 80%) was used without any further purification

実験手順

α-chloroacetylchloride (10.1 g, 0.128 mole) was added dropwise under stirring at room temperature to the 2-aminohydroquinone (4.16 g, 0.128 mole) in dry acetone (400 ml) and diethanolamine (2.04 ml, 0.128 mole). The reaction mixture was poured into water and hydrochloride acid (2,000 ml, pH 1), then extracted with ethylacetate (500 ml). The solvent was evaporated to dryness and the solid residue (4.20 g, 80%) was used without any further purification. The structure of the 2-(α-chloroacetamido)-hydroquinone was confirmed by NMR analysis.

出典