反応 #6296

反応方程式

4-fluorobenzaldehyde

N-butyl-N-4-hydroxybutylamine

potassium carbonate

→

4-(N-4-hydroxybutyl-N-butylamino)benzaldehyde

溶媒

dimethylsulfoxide

反応条件

後処理

1. 1
   その他To a three neck flask fitted with a mechanical stirrer
2. 2
   温度After cooling to room temperature
3. 3
   ろ過the solid product is collected by filtration
4. 4
   その他purified by recrystallization from tetrahydrofuran/benzene

実験手順

To a three neck flask fitted with a mechanical stirrer, a thermometer, and a condenser, is added 124 g (1 mole) of 4-fluorobenzaldehyde, 145.3 g (1 mole) of N-butyl-N-4-hydroxybutylamine, 138.2 g (1 mole) of anhydrous potassium carbonate, and dimethylsulfoxide. The mixture is then heated at 95° C. until the reaction is complete. After cooling to room temperature, the solution is poured into a four-fold excess of ice water, and the solid product is collected by filtration and purified by recrystallization from tetrahydrofuran/benzene.

出典