反応 #62946

反応方程式

5-acetamido-2-mercapto-1,3-thiazole

bromoacetic acid

→

title compound

収率 67.0%

5-Acetamido-2-carboxymethylthio-1,3-thiazole

収率 67.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他The solvent was then removed in vacuo
2. 2
   洗浄the solid residue was washed with diethyl ether
3. 3
   その他After recrystallization from isopropanol/diethyl ether

実験手順

3.48 g (20 mmol) of 5-acetamido-2-mercapto-1,3-thiazole were dissolved in 90 ml of dry DMF, 2.78 g (20 mmol) of bromoacetic acid were added, and the mixture was stirred at room temperature for 2 hours. The solvent was then removed in vacuo, and the solid residue was washed with diethyl ether. After recrystallization from isopropanol/diethyl ether, 3.1 g (67%) of the title compound were obtained.

出典