反応 #62889

反応方程式

KOH

p-aminophenol

1-methyl-3-trifluoromethyl-5-methylsulfonyl-1H-1,2,4-triazole

→

1-methyl-3-trifluoromethyl-5-(4-aminophenoxy)-1H-1,2,4-triazole

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction mixture is stirred for a further 2 hours
2. 2
   その他The precipitated product is isolated by filtration
3. 3
   洗浄washed with water
4. 4
   その他dried
5. 5
   その他111°14 112° C.

実験手順

8 g of pulverised KOH are added to 10.9 g of p-aminophenol in 120 ml of dimethyl sulfoxide, and the mixture is stirred for 1/2 hour. Then 22.9 g of 1-methyl-3-trifluoromethyl-5-methylsulfonyl-1H-1,2,4-triazole are added, the reaction mixture is stirred for a further 2 hours and subsequently poured into 1 liter of ice water. The precipitated product is isolated by filtration, washed with water and dried. Yield: 19.6 g (76% of theory). Melting point: 111°14 112° C.

出典