反応 #62878

反応方程式

Sodium borohydride

4-bromo-2,3,5,6-tetrafluorobenzaldehyde

water

→

4-bromo-2,3,5,6-tetrafluorobenzyl alcohol

収率 90.8%

溶媒

methanol

反応条件

後処理

1. 1
   温度was maintained within the range from -5° C. to +5° C.
2. 2
   ろ過the precipitated white solid collected by filtration
3. 3
   洗浄washed with water and air
4. 4
   その他dried

実験手順

Sodium borohydride (1.0 g) was added portionwise over a period of 30 minutes to a stirred solution of 4-bromo-2,3,5,6-tetrafluorobenzaldehyde (8.2 g) in methanol (80 cm3) whilst the temperature was maintained within the range from -5° C. to +5° C., after which the mixture was stirred for 2 hours at the ambient temperature (ca. 18° C.). The mixture was poured into water and the precipitated white solid collected by filtration, washed with water and air dried to yield 4-bromo-2,3,5,6-tetrafluorobenzyl alcohol (7.5 g), m.p. 60°-62° C.

出典