反応 #628751

反応方程式

4-Bromo-1-fluoro-2-nitrobenzene

potassium carbonate

2-propanethiol

→

desired compound

収率 96.6%

4-Bromo-1-(isopropylthio)-2-nitrobenzene

収率 96.6%

溶媒

N,N-dimethylformamide

water

反応条件

後処理

1. 1
   温度The mixture was cooled to rt
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The extracts were washed with brine
4. 4
   乾燥dried over sodium sulfate
5. 5
   その他evaporated

実験手順

4-Bromo-1-fluoro-2-nitrobenzene (1.0 g, 4.5 mmol) [Aldrich] and potassium carbonate (1.6 g, 11 mmol) were stirred in N,N-dimethylformamide (10 mL), and 2-propanethiol (0.42 mL, 4.5 mmol) was added. The mixture was heated to 100° C. for 16 hours. The mixture was cooled to rt, diluted with water (100 mL), and extracted with ethyl acetate. The extracts were washed with brine, dried over sodium sulfate, and evaporated to give the desired compound (1.2 g, 96%). 1H NMR (300 MHz, CDCl3): δ 8.27 (s, 1H), 7.62 (d, 1H), 7.38 (d, 1H), 3.55 (m, 1H), 1.40 (d, 6H).

出典