反応 #62860

ord-c81735eec3d444498777a128b2160c42

反応方程式

Cc1c(Cl)ccc(C(=O)O)c1Cl
2,4-dichloro-3-methylbenzoic acid
O=S(=O)(O)O
H2SO4
O=[N+]([O-])[O-].[K+]
KNO3
→
Cc1c(Cl)c(C(=O)O)cc([N+](=O)[O-])c1Cl
nitro
Cc1c(Cl)c(C(=O)O)cc([N+](=O)[O-])c1Cl
2,4-Dichloro-3-methyl-5-nitrobenzoic acid

反応物

Cc1c(Cl)ccc(C(=O)O)c1Cl
2,4-dichloro-3-methylbenzoic acid
O=S(=O)(O)O
H2SO4
O=[N+]([O-])[O-].[K+]
KNO3

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    温度while cooling with ice
  2. 2
    温度The mixture is subsequently warmed at 50° for a further 2 hours
  3. 3
    workup.ADDITIONpoured onto ice

実験手順

30 g of 2,4-dichloro-3-methylbenzoic acid are initially introduced into 83 ml of concentrated H2SO4. 16.7 g of KNO3 are added in portions, while cooling with ice. The mixture is subsequently warmed at 50° for a further 2 hours and then poured onto ice. The nitro compound is isolated and recrystallized from toluene. Melting point: 152°-4°, yield: 24 g.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04762844uspto-grants-1988_08