反応 #62855

反応方程式

2-chloro-5-fluoro-4-methylbenzoic acid

KNO3

→

2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

溶媒

H2SO4

反応条件

後処理

1. 1
   温度while cooling with ice
2. 2
   温度The mixture is then warmed to 50° for 2 hours
3. 3
   workup.ADDITIONsubsequently poured onto ice
4. 4
   その他After isolation and recrystallization from toluene, 18.8 g of 2-chloro-5-fluoro-4-methyl-3-nitrobenzoic acid of melting point 186°-88°
5. 5
   その他are obtained

実験手順

20 g of 2-chloro-5-fluoro-4-methylbenzoic acid are initially introduced into 60 ml of concentrated H2SO4. 12.3 g of KNO3 are added in portions, while cooling with ice. The mixture is then warmed to 50° for 2 hours and subsequently poured onto ice. After isolation and recrystallization from toluene, 18.8 g of 2-chloro-5-fluoro-4-methyl-3-nitrobenzoic acid of melting point 186°-88° are obtained.

出典