反応 #62830

反応方程式

5-fluoroisatin

triethylamine

methyl isocyanate

→

5-fluoro-1-methylcarbamoylisatin

収率 74.5%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGThe mixture is stirred at room temperature for 30 minutes
3. 3
   ろ過the precipitates are taken by filtration

実験手順

A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.

出典