反応 #62780

反応方程式

benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-iodomethyl-3-cephem-4-carboxylate-1-oxide

N-methylpyrrolidine

diisopropyl ether

→

benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-(1-methyl-1-pyrrolidiniomethyl)-3-cephem-4-carboxylate-1-oxide iodide

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他The resultant precipitates
2. 2
   ろ過were collected by filtration
3. 3
   洗浄washed with diisopropyl ether
4. 4
   その他air-dried

実験手順

A solution of benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-iodomethyl-3-cephem-4-carboxylate-1-oxide (syn isomer) (1.97 g) and N-methylpyrrolidine (204 mg) in tetrahydrofuran (10 ml) was stirred for 40 minutes at 0°-5° C. and then diisopropyl ether was added thereto. The resultant precipitates were collected by filtration, washed with diisopropyl ether and air-dried to give benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-(1-methyl-1-pyrrolidiniomethyl)-3-cephem-4-carboxylate-1-oxide iodide (syn isomer) (2.12 g).

出典