反応 #6272

反応方程式

4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine

hydrochloric acid methanol

→

desired compound

収率 85.6%

4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine dihydrochloride

収率 85.6%

溶媒

methanol

反応条件

後処理

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   その他the residue was purified by recrystallization (solvent: ethanol-ether)

実験手順

To a solution of 704.5 mg (2.57 mmol) of 4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine in 30 ml of methanol, 70 ml of 10% hydrochloric acid-methanol was added, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off and the residue was purified by recrystallization (solvent: ethanol-ether) to give 842.4 mg of the desired compound (85.6% yield, pale yellow crystals).

出典