反応 #62689

反応方程式

2-cyanoethy 3-oxobutanoate

methyl 3-aminocrotonate

3-nitrobenzaldehyde

→

racemic 2,6-dimethyl-3-carbomethoxy-4-(3-nitrophenyl)-5-(2-cyano)ethoxycarbonyl-1,4-dihydropyridine

溶媒

methanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 8 hours
3. 3
   ろ過The resulting precipitate was filtered
4. 4
   洗浄washed with methanol
5. 5
   その他dried

実験手順

A mixture of 2-cyanoethy 3-oxobutanoate (83.3 g, 0.54 mol), methyl 3-aminocrotonate (61.9 g, 0.54 mol), and 3-nitrobenzaldehyde (81.3 g, 0.54 mol) in methanol (540 mL ) was heated at reflux for 8 hours, then stirred overnight. The resulting precipitate was filtered, washed with methanol, and dried to produce racemic 2,6-dimethyl-3-carbomethoxy-4-(3-nitrophenyl)-5-(2-cyano)ethoxycarbonyl-1,4-dihydropyridine (mp=123° C.).

出典