反応 #6264

反応方程式

2,4-thiazolidinedione

benzaldehyde

piperidine

→

desired compound

収率 90.4%

5-benzylidene-2,4-thiazolidinedione

収率 90.4%

溶媒

ethanol

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度under reflux for 5 hours
3. 3
   温度After cooling
4. 4
   ろ過the precipitated crystals were filtered
5. 5
   洗浄washed with cooled ethanol

実験手順

To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of benzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 31.67 g of the desired compound (90.4% yield, pale yellow crystals).

出典