反応 #62608

反応方程式

compound

Methyl 4-oxo-4-(4-dimethylcarbamoylthiophenyl)butanoate

Sodium

water

HCl

→

title compound

Methyl 4-oxo-4-(4-mercaptophenyl)butanoate

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONpoured into a mixture
2. 2
   ろ過The resulting yellow solid was collected by filtration
3. 3
   洗浄washed with water
4. 4
   その他dried in air

実験手順

Sodium (280 mg) was dissolved in anhydrous methanol (50 ml) under a N2 atmosphere. To the resulting solution there was added 5.0 g of the compound from Step 4. The mixture was stirred at room temperature overnight, then poured into a mixture containing 30 ml of water and 7 ml of concentrated HCl. The resulting yellow solid was collected by filtration, washed with water and dried in air to give the title compound, m.p. 83°-84°.

出典