反応 #62604

反応方程式

ester

Methyl 2-methoxy-7-(((4-methoxyphenyl)methyl)thio)quinolin-3-carboxylate

formic acid

water

H2S

→

title compound

Methyl 7-mercapto-2-methoxyquinolin-3- carboxylate

溶媒

CH2Cl2

反応条件

後処理

1. 1
   workup.WAITwas passed through the vigorously stirred mixture for 5 minutes
2. 2
   その他The organic phase was separated
3. 3
   ろ過filtered through celite
4. 4
   洗浄washed with water
5. 5
   乾燥dried (MgSO4)

実験手順

A mixture of the ester from Step 4 (2.77 g), 90% formic acid (70 ml) and mercuric acetate (7.17 g) was stirred under an argon atmosphere at ambient temperature for 3 hours. The reaction mixture was poured into a mixture of water (350 ml) and CH2Cl2 (700 ml) and H2S gas was passed through the vigorously stirred mixture for 5 minutes. The organic phase was separated, filtered through celite, washed with water, dried (MgSO4) and reduced to dryness to provide the title compound, m.p. 103°-105°.

出典