反応 #62582

反応方程式

dl-2-amino-1-propanol

hexadecanoyl chloride

→

title compound

収率 51.0%

2-(N-Hexadecanoyl)amino-1-propanol

収率 51.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   濃縮The solution was concentrated
2. 2
   その他decanted
3. 3
   濃縮The solution was concentrated
4. 4
   その他the residue was chromatographed on silica gel using 50% ethylacetate in hexane

実験手順

A solution of 4.00 g (53.2 mmol) of commercially obtained dl-2-amino-1-propanol b and 8.0 g (8.8 ml, 29.3 mmol) of hexadecanoyl chloride in 100 ml of CH2Cl2 was stirred at room temperature for hours. The solution was concentrated and the residue was boiled with 200 ml acetone and decanted. The solution was concentrated and the residue was chromatographed on silica gel using 50% ethylacetate in hexane to afford 4.15 g (51%) of the title compound as white needles, m.p. 75-76° C. Using the same procedure as in Example 19, the following compounds were prepared:

出典