反応 #6258

反応方程式

4-(4-phthalimidobutyloxy)pyridine

hydrogen chloride methanol

→

desired compound

収率 86.3%

4-(4-phthalimidobutyloxy)pyridine hydrochloride

収率 86.3%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISSOLUTIONdissolve
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   その他the residue was crystallized from acetone-ether
5. 5
   ろ過The resulting crystals were collected by filtration
6. 6
   洗浄washed with ether

実験手順

To a suspension of 1.48 g (5.0 mmol) of 4-(4-phthalimidobutyloxy)pyridine in 20 ml of methanol, 15 ml of hydrogen chloride-methanol was added and dissolve. The solvent was distilled off and the residue was crystallized from acetone-ether. The resulting crystals were collected by filtration and washed with ether to give 1.51 g of the desired compound (86.3% yield, colorless crystals), mp. 154°-156° C.

出典