反応 #6257

反応方程式

4-(3-phthalimidopropyloxy)pyridine

hydrogen chloride methanol

→

desired compound

収率 64.8%

4-(3-phthalimidopropyloxy)pyridine hydrochloride

収率 64.8%

溶媒

methanol

反応条件

後処理

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   workup.ADDITIONacetone was added to the residue
3. 3
   ろ過The resulting crystals were collected by filtration
4. 4
   洗浄washed with acetone

実験手順

To a solution of 1.41 g (5.0 mmol) of 4-(3-phthalimidopropyloxy)pyridine in 20 ml of methanol, 10 ml of hydrogen chloride-methanol was added. The solvent was distilled off and acetone was added to the residue. The resulting crystals were collected by filtration and washed with acetone to give 1.03 g of the desired compound (64.8% yield, colorless crystals), mp. 167°-169° C.

出典