反応 #62548

反応方程式

Methyl chloroacetate

N-methylpiperazine

→

2-(4-methyl-1-piperazinyl)acetic acid, methyl ester

収率 95.0%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered
2. 2
   その他the solvent was removed under vacuum
3. 3
   workup.DISSOLUTIONThe resulting oil was dissolved in methylene chloride-methanol (9:1)
4. 4
   その他purified by flash chromatography (silica)

実験手順

Methyl chloroacetate (8.8 ml., 0.10 mole) was added to a solution of N-methylpiperazine (24.4. ml., 0.22 mole) in ethyl acetate (140 ml.) and the mixture was stirred for 17 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting oil was dissolved in methylene chloride-methanol (9:1) and purified by flash chromatography (silica) to give 2-(4-methyl-1-piperazinyl)acetic acid, methyl ester as an oil (16.3 g, 95%).

出典