反応 #62488

反応方程式

6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline

pentafluorophenyl-tetramethyluronium hexafluorophosphate

diisopropylethylamine

piperidine-4-carboxylic acid amide

→

6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-(4-aminocarbonyl-piperidin-1-yl-carbonyl)-quinazoline

溶媒

DMSO

反応条件

実験手順

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and piperidine-4-carboxylic acid amide in DMSO at ambient temperature.

出典