反応 #62404

反応方程式

acetic anhydride

4-bromo-5-fluoro-2-methylphenylamine

→

title compound

N-(4-Bromo-5-fluoro-2-methylphenyl)acetamide

反応条件

後処理

1. 1
   workup.DISTILLATIONExcess acetic anhydride was distilled off under reduced pressure
2. 2
   洗浄the precipitated crystals were washed with water

実験手順

73.6 mL of acetic anhydride was added with 80.0 g of 4-bromo-5-fluoro-2-methylphenylamine at room temperature, and stirred at this temperature for 10 minutes. Excess acetic anhydride was distilled off under reduced pressure, and the precipitated crystals were washed with water, to afford 77.6 g of the title compound as colorless crystal.

出典