反応 #62396

反応方程式

5-acetoxymethyl-2-furanaldehyde

morpholine

sodium triacetoxy borohydride

→

title compound

Acetic acid 5-(morpholin-4-yl)methyl-furan-2-ylmethyl ester

溶媒

1,2-dichloroethane

dichloromethane

反応条件

後処理

1. 1
   洗浄washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
2. 2
   乾燥dried over anhydrous magnesium sulfate
3. 3
   その他The solvent was evaporated
4. 4
   その他the residue was purified
5. 5
   その他separated by silica gel column chromatography

実験手順

Under nitrogen atmosphere, to a solution of 2.0 g of 5-acetoxymethyl-2-furanaldehyde and 1.1 mL of morpholine in 35 mL of 1,2-dichloroethane was added 4.0 g of sodium triacetoxy borohydride at room temperature, and stirred at this temperature for 3 hours. The reaction solution was diluted with dichloromethane, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified and separated by silica gel column chromatography, to afford 2.3 g of the title compound as a colorless oil.

出典