反応 #62349

反応方程式

sodium thiosulfate

(2-chlorothiophen-3-yl)methanol

N-bromosuccinimide

→

title compound

収率 80.6%

(5-Bromo-2-chlorothiophen-3-yl)methanol

収率 80.6%

溶媒

ethyl acetate

dimethylformamide

反応条件

後処理

1. 1
   洗浄The organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
2. 2
   乾燥dried over anhydrous magnesium sulfate
3. 3
   その他the solvent was evaporated

実験手順

To a solution of 3.0 g of (2-chlorothiophen-3-yl)methanol in 60 mL of dimethylformamide was added 3.59 g of N-bromosuccinimide at room temperature, and stirred at this temperature for 2 hours. Adding 10 mL of 10% sodium thiosulfate, and the resultant solution was diluted with ethyl acetate. The organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 3.7 g of the title compound as a colorless oil.

出典