反応 #62306

ord-c147f8ec689548fc837ab12dc8208f0e

反応方程式

O=C(O)c1cc(F)c2c(c1)c(/C=C/c1cccnc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1
7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-carboxylic acid
O=C(O)c1cc(F)c2c(c1)c(/C=C/c1cccnc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1
7-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic acid
CC(C)[C@H](N)CO
L-valinol
→
CC(C)[C@@H](CO)NC(=O)c1cc(F)c2[nH]nc(/C=C/c3cccnc3)c2c1
title compound
CC(C)[C@@H](CO)NC(=O)c1cc(F)c2[nH]nc(/C=C/c3cccnc3)c2c1
7-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-carboxylic acid [(1S)-1-hydroxymethyl-2-methylpropyl]-amide

反応物

O=C(O)c1cc(F)c2c(c1)c(/C=C/c1cccnc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1
7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-carboxylic acid
O=C(O)c1cc(F)c2c(c1)c(/C=C/c1cccnc1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1
7-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic acid
CC(C)[C@H](N)CO
L-valinol

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

By treating 200 mg of 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-carboxylic acid obtained by Example 126 and 94.5 μl L-valinol in accordance with Example 127, 102 mg of the title compound was obtained as white crystals.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07429609B2uspto-grants-2008_09