反応 #62302

反応方程式

3-bromo-7-fluoro-1-trityl-1H-indazole-5-carbonitrile

vinyltributyltin

→

title compound

7-Fluoro-1-trityl-3-vinyl-1H-indazole-5-carbonitrile

溶媒

toluene

反応条件

後処理

1. 1
   温度After cooling to room temperature
2. 2
   workup.ADDITION10 g of silica gel was added
3. 3
   その他the solvent was evaporated
4. 4
   その他followed by purification by silica gel column chromatography

実験手順

Under nitrogen atmosphere, 3.32 g of 3-bromo-7-fluoro-1-trityl-1H-indazole-5-carbonitrile was dissolved in 100 mL of toluene, added with 398 mg of tetrakis(triphenylphosphilne)palladium(0) and 2.50 mL of vinyltributyltin, and stirred at 100° C. for 95 minutes. After cooling to room temperature, 10 g of silica gel was added, the solvent was evaporated, followed by purification by silica gel column chromatography, to afford 2.59 g of the title compound as white crystals.

出典