反応 #62300

反応方程式

5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde

cesium fluoride

→

title compound

収率 75.6%

5-Bromo-2,3-difluoro Benzaldehyde

収率 75.6%

溶媒

N,N-dimethylformamide

water

ethyl acetate

反応条件

後処理

1. 1
   洗浄the organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
2. 2
   乾燥dried over anhydrous magnesium sulfate
3. 3
   その他the solvent was evaporated

実験手順

To a solution of 18.0 g of 5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde in 20 mL of N,N-dimethylformamide and 2 mL of water was added 1.63 g of cesium fluoride at room temperature, and stirred at this temperature for 1 hour. After diluting with ethyl acetate, the organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 10.26 g of the title compound as a colorless oil.

出典