反応 #622861

反応方程式

5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide

5-Fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide

1-(5-(2-bromoethyl)indolin-1-yl)ethanone

1-(5-(2-Bromoethyl)indolin-1-yl)ethanone

→

title compound

7-(4-(2-(1-Acetylindolin-5-yl)ethyl)piperazin-1-yl)-5-fluoro-N,N-dimethylbenzofuran-2-carboxamide

反応条件

後処理

1. 1
   その他The compound was prepared
2. 2
   その他The product was purified by preparative HPLC

実験手順

The compound was prepared according to the procedure disclosed in Example 50 starting from 5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.10 g, 0.35 mmol) (Example 50g) and 1-(5-(2-bromoethyl)indolin-1-yl)ethanone (0.13 g, 0.49 mmol) (Example 49b). The product was purified by preparative HPLC to give the title compound.

出典