反応 #62166

反応方程式

water

2-Chloromethyl-quinoline

4-Hydroxy-benzamide

cesium carbonate

→

title compound

収率 45.0%

4-(Quinolin-2-ylmethoxy)-benzamide

収率 45.0%

溶媒

dimethyl formamide

反応条件

後処理

1. 1
   抽出extracted with chloroform, dried magnesium sulfate
2. 2
   ろ過filtered
3. 3
   濃縮concentrated

実験手順

To a solution of 2-Chloromethyl-quinoline (1.57 g) and 4-Hydroxy-benzamide (995 mg) in dimethyl formamide (20 mL) was added cesium carbonate (7.3 g) and the reaction mixture heated at 80° C. for 18 h. The reaction mixture was poured into water and extracted with chloroform, dried magnesium sulfate, filtered and concentrated to provided the title compound (909 mg). MS: (M+H -m/z=279.3).

出典