反応 #62163

反応方程式

4-(Quinolin-2-ylmethoxy)-phenylamine

tin

sodium nitrite

→

title compound

[4-(Quinolin-2-ylmethoxy)-phenyl]-hydrazine

溶媒

HCl

HCl

反応条件

後処理

1. 1
   workup.ADDITIONadded slowly dropwise
2. 2
   ろ過The reaction mixture was filtered
3. 3
   その他the solid dried

実験手順

To a suspension of 4-(Quinolin-2-ylmethoxy)-phenylamine (1.73 g) in 30 mL of concentrated HCl at 0° C. was added sodium nitrite (531 mg). After 3 h, tin chlrodie (3.95 g) was dissolved in 20 mL of concentrated HCl and added slowly dropwise and the reaction mixture stirred at ambient temperature for 18 h. The reaction mixture was filtered and the solid dried to provide the title compound as the HCL salt (3.94 g). MS: (M+H m/z=266.3).

出典