反応 #62152

反応方程式

sodium bicarbonate

acetic acid

(4-Benzyloxy-phenyl)-hydrazine hydrogen chloride

→

title compound

2-(4-Benzyloxy-phenyl-2H-pyrazol-3-yl]-pyridine

溶媒

methanol

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate, dried magnesium sulfate
2. 2
   ろ過filtered
3. 3
   濃縮concentrated
4. 4
   その他Purification via combiflash MPLC

実験手順

To a solution of 3-Dimethylamino-1-pyridin-4-yl-propenone (590 mg) in methanol (10 ml) was added acetic acid (0.5 ml) and (4-Benzyloxy-phenyl)-hydrazine hydrogen chloride (836 mg) and the reaction mixture heated to 60° C. for 6 h. The reaction mixture was poured into saturated sodium bicarbonate, extracted with ethyl acetate, dried magnesium sulfate, filtered and concentrated. Purification via combiflash MPLC provided the title compound (795 mg). MS: (M+H m/z=328.1).

出典