反応 #62144

反応方程式

4-(2-Quinolin-2-yl-ethyl)-benzoic acid

acetonitrile

O,N-Dimethyl-hydroxylamine hydrogen chloride

sodium hydroxide

→

title compound

収率 88.0%

N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide

収率 88.0%

溶媒

dioxane

triethylamine

反応条件

後処理

1. 1
   抽出extracted with chloroform, dried magnesium sulfate
2. 2
   ろ過filtered
3. 3
   濃縮concentrated
4. 4
   洗浄Biotage MPLC chromatography eluting with 20-50% ethyl acetate

実験手順

To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid (530 mg) in dioxane 5 ml/acetonitrile 5 ml was added triethylamine (0.60 ml) and O,N-Dimethyl-hydroxylamine hydrogen chloride (240 mg). After 72 h, the reaction mixture was poured into 1N sodium hydroxide solution and extracted with chloroform, dried magnesium sulfate, filtered and concentrated. Biotage MPLC chromatography eluting with 20-50% ethyl acetate provided the title compound (516 mg, 88%). MS: (M+H m/z=321.1).

出典