反応 #62078

反応方程式

[4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-thianthren-1-yloxy]-acetic acid methyl ester

sodium hydroxide

→

title compound

[4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-thianthren-1-yloxy]-acetic acid sodium salt

溶媒

methanol

反応条件

後処理

1. 1
   その他was removed in vacuo

実験手順

To a solution of [4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-thianthren-1-yloxy]-acetic acid methyl ester (1.41 g, 2.91 mmol) in anhydrous methanol (10 ml) was added sodium hydroxide (120 mg, 2.91 mmol) in a single portion. The solution was then stirred at room temperature for 24 hours whereupon the solvent was removed in vacuo to give the title compound as an off white paste (1.43 g, 98%) that required no further purification. m/z (LC-MS, ESP): RT=3.79 min, (M−−23)=468

出典