反応 #62044

反応方程式

HCl

4-Isothiocyanato-benzoic acid t-butyl ester

4-isothiocyanato-benzoic acid t-butyl ester

KOH

cyanoacetamide

→

4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

収率 83.5%

4-(2-carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

収率 83.5%

溶媒

DMF

反応条件

後処理

1. 1
   その他the precipitate obtained
2. 2
   ろ過was filtered
3. 3
   洗浄washed with water
4. 4
   その他dried under vacuum

実験手順

4-Isothiocyanato-benzoic acid t-butyl ester 2 (28.3 gm, 120.4 mmol) was taken into DMF (200 ml). To this KOH (6.74 gm, 120.4 mmol) and cyanoacetamide (10.21 gm, 120.4 mmol) were added. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was acidified with 1N HCl, the precipitate obtained was filtered, washed with water, and dried under vacuum, to provide 32.10 gm of 4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester 3.

出典