反応 #62017

反応方程式

4-cyanoisophthalic acid

HCl

→

4-aminomethylisophthalic acid

溶媒

ethanol

反応条件

後処理

1. 1
   その他was hydrogenated at 50 PSI overnight
2. 2
   その他The solid impurities were removed by filtration
3. 3
   その他Removal of solvent

実験手順

A pressure flask was charged with 4-cyanoisophthalic acid 204 (1.40 g, 7.33 mmol), ethanol (100 mL), Pd/C (10%) (0.50 mg), and concentrated HCl (1.5 mL). The mixture solution was hydrogenated at 50 PSI overnight. The solid impurities were removed by filtration. Removal of solvent gave quantitative yield of 4-aminomethylisophthalic acid 205: 1H NMR (400 MHz, CD3OD) δ 4.46 (s, 2H), 7.69 (d, J=8 Hz, 1H), 8.26 (dd, J=2 Hz, J=8 Hz, 1H), 8.76 (d, J=1.7 Hz, 1H).

出典