反応 #61975

反応方程式

sodium bicarbonate

4-hydroxybenzaldehyde

piperidine

sodium triacetoxyborohydride

→

title compound

4-Piperidin-1-ylmethyl-phenol

溶媒

DCE

acetic acid

反応条件

後処理

1. 1
   抽出extracted with DCM (5×100 mL)
2. 2
   乾燥The combined organic phases were dried (magnesium sulfate)
3. 3
   その他evaporated

実験手順

A solution of 4-hydroxybenzaldehyde (10 g), piperidine (8.9 mL), and acetic acid (4.7 mL) in DCE (200 mL) was treated with sodium triacetoxyborohydride (24 g). After 16 h, the resulting mixture was treated with saturated aqueous sodium bicarbonate (100 mL) and extracted with DCM (5×100 mL). The combined organic phases were dried (magnesium sulfate) and evaporated. Trituration of the residue with ethyl acetate gave the title compound as a white crystalline solid (5.5 g).

出典