反応 #61971

反応方程式

4-(3-chloro-1-propoxy)iodobenzene

piperidine

sodium carbonate

→

title compound

1-[3-(4-Iodo-phenoxy)-propyl]-piperidine

溶媒

n-butanol

water

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   抽出extracted with methylene chloride (2×20 mL)
3. 3
   乾燥The combined organic phases were dried (magnesium sulfate)
4. 4
   その他evaporated in vacuo
5. 5
   workup.DISTILLATIONKugelrohr distillation of the residue (5 mm Hg, 260° C.)

実験手順

A suspension of 4-(3-chloro-1-propoxy)iodobenzene (5 g), piperidine (2.2 mL), sodium carbonate (2.7 g), and potassium iodide (140 mg) in n-butanol (30 mL) was heated in a 105° C. bath for 18 h. The resulting mixture was allowed to cool to room temperature, diluted with water (50 mL), and extracted with methylene chloride (2×20 mL). The combined organic phases were dried (magnesium sulfate), and evaporated in vacuo. Kugelrohr distillation of the residue (5 mm Hg, 260° C.) gave the title compound as a white crystalline solid (4.8 g).

出典