反応 #61969

反応方程式

potassium carbonate

piperidine

ethanol water

3-bromopropan-1-ol

→

title compound

3-Piperidin-1-yl-propan-1-ol

溶媒

water

Dichloromethane

反応条件

後処理

1. 1
   抽出the aqueous phase was extracted with dichloromethane (2×100 mL)
2. 2
   乾燥The combined organic extracts were dried (magnesium sulfate)
3. 3
   その他evaporated in vacuo
4. 4
   workup.DISTILLATIONKugelrohr distillation of the residue (5-10 mm Hg, 120° C.)

実験手順

A solution of potassium carbonate (24.9 g) and piperidine (130 mL) in 1:1 ethanol-water (130 mL) was treated with 3-bromopropan-1-ol (25.0 g). The resulting mixture was stirred vigorously for 20 h. Dichloromethane (200 mL) and water (50 mL) were added and the aqueous phase was extracted with dichloromethane (2×100 mL). The combined organic extracts were dried (magnesium sulfate) and evaporated in vacuo. Kugelrohr distillation of the residue (5-10 mm Hg, 120° C.) gave the title compound as a colorless oil (13.9 g).

出典