反応 #619160

反応方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

4-methanesulfonyl-piperazine hydrochloride

sodium triacetoxyborohydride

→

desired product

収率 38.6%

1,1-Dicyclohexyl-3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea

収率 38.6%

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (50 mg, 0.15 mmol), 4-methanesulfonyl-piperazine hydrochloride (45 mg, 0.23 mmol) and sodium triacetoxyborohydride (40 mg, 0.19 mmol) to afford 28 mg (38%) of the desired product after purification.

出典