反応 #619158

反応方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

1-piperazinyl-1-propanone

sodium triacetoxyborohydride

→

desired product

収率 15.0%

1,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea

収率 15.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (60 mg, 0.18 mmol), 1-piperazinyl-1-propanone (39 mg, 0.22 mmol), catalytic acetic acid and sodium triacetoxyborohydride (47 mg, 0.22 mmol) to afford 12 mg (15%) of the desired product after purification.

出典