反応 #619157

反応方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

4-piperidone hydrochloride

sodium triacetoxyborohydride

→

desired product

収率 12.0%

1,1-Dicyclohexyl-3-[5-(4-oxo-piperidin-1-ylmethyl)-thiazol-2-yl]-urea

収率 12.0%

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (34 mg, 0.10 mmol), 4-piperidone hydrochloride (46 mg, 0.30 mmol) and sodium triacetoxyborohydride (25 mg, 0.12 mmol) to afford 5 mg (12%) of the desired product after purification.

出典