反応 #619156

反応方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

1,1-dioxo-thiomorpholine hydrochloride

sodium triacetoxyborohydride

→

desired product

収率 18.0%

1,1-Dicyclohexyl-3-[5-(1,1-dioxo-thiomorpholin-4-ylmethyl)-thiazol-2-yl]-urea

収率 18.0%

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (67 mg, 0.20 mmol), 1,1-dioxo-thiomorpholine hydrochloride (52 mg, 0.30 mmol) and sodium triacetoxyborohydride (51 mg, 0.24 mmol) to afford 16 mg (18%) of the desired product after purification.

出典