反応 #619153

反応方程式

sodium triacetoxyborohydride

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

acetic acid

morpholine

→

desired product

収率 34.4%

1,1-Dicyclohexyl-3-(5-morpholin-4-ylmethyl-thiazol-2-yl)-urea

収率 34.4%

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (100 mg, 0.30 mmol), acetic acid (18 μL, 0.30 mmol), morpholine (78 μL, 0.90 mmol) and sodium triacetoxyborohydride (70 mg, 0.33 mmol) to afford 42 mg (34%) of the desired product after purification.

出典