反応 #619149

反応方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

glycine tert-butyl ester hydrochloride

sodium triacetoxyborohydride

→

desired product

収率 68.8%

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester

収率 68.8%

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (67 mg, 0.20 mmol), glycine tert-butyl ester hydrochloride (50 mg, 0.30 mmol) and sodium triacetoxyborohydride (59 mg, 0.28 mmol) to afford 62 mg (68%) of the desired product after purification.

出典