反応 #619143

反応方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

cyclopentylamine

sodium triacetoxyborohydride

→

desired product

収率 37.1%

1,1-Dicyclohexyl-3-(5-cyclopentylaminomethyl-thiazol-2-yl)-urea

収率 37.1%

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (100 mg, 0.30 mmol), cyclopentylamine (45 μL, 0.45 mmol) and sodium triacetoxyborohydride (102 mg, 0.48 mmol) to afford 45 mg (37%) of the desired product after purification.

出典