反応 #619137

ord-0338da0fb1c04a90ac7f005495ccc472

反応方程式

CCS(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CC[NH2+]CC3)s2)CC1
4-{1 -cyclohexyl-3-[5-(4-ethanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidinium
[Cl-]
chloride
O=C(Cl)C1CCCC1
cyclopentanecarbonyl chloride
→
CCS(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CCN(C(=O)C4CCCC4)CC3)s2)CC1
1-Cyclohexyl-1-(1-cyclopentanecarbonyl-piperidin-4-yl)-3-[5-(4-ethanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea

反応物

CCS(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCC3)C3CC[NH2+]CC3)s2)CC1
4-{1 -cyclohexyl-3-[5-(4-ethanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidinium
[Cl-]
chloride
O=C(Cl)C1CCCC1
cyclopentanecarbonyl chloride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他Prepared in 65% (193 mg)
  2. 2
    その他yield

実験手順

Prepared in 65% (193 mg) yield as described in general procedure (N) from 4-{1 -cyclohexyl-3-[5-(4-ethanesulfonyl-piperazin-1-ylmethyl)-thiazol-2-yl]-ureido}-piperidinium; chloride (268 mg, 0.5 mmol) and cyclopentanecarbonyl chloride (80 mg, 0.6 mmol).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: USRE045183E1uspto-grants-2014_10