反応 #619117

反応方程式

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

収率 47.7%

溶媒

methanol

反応条件

後処理

1. 1
   その他The content was degassed
2. 2
   ろ過The mixture was filtered through celite
3. 3
   濃縮the filtrate was concentrated
4. 4
   その他The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

実験手順

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

出典