反応 #619087

反応方程式

water

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea

NCS

→

3-(5-Chloro-thiazol-2-yl)-1-cyclohexyl-1-piperidin-1-yl-urea

溶媒

DCM

DCM

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   乾燥The organic phase was dried (MgSO4)
3. 3
   その他the solvent was removed in vacuo
4. 4
   workup.ADDITIONMeCN (1 mL) was added whereupon the product
5. 5
   その他precipitated
6. 6
   ろ過The product was filtered off
7. 7
   その他dried

実験手順

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea (50 mg, 0.16 mmol), prepared in an identical manner to Example 94 was dissolved in DCM (1 mL) and NCS (26 mg, 0.19 mmol)) was added. The reaction mixture was stirred for 3 days before DCM (20 mL) and water (20 mL) was added. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. MeCN (1 mL) was added whereupon the product precipitated. The product was filtered off and dried. Yield: 20 mg.

出典