反応 #61797

反応方程式

water

2-Chloromethyl-6-(4-trifluoromethoxy-phenyl)-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

収率 18.8%

2-[4-(4-[1,2,3]Triazol-1-yl-butyl)-phenoxymethyl]-6-(4-trifluoromethoxy-phenyl)-pyridine

収率 18.8%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITcontinued at r.t. over night
3. 3
   その他the precipitate was isolated
4. 4
   洗浄washed thoroughly with water, n-heptane and diethylether
5. 5
   その他The residue was dried at 40° C.

実験手順

A solution of 37 mg (0.17 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 2.0 ml N,N-dimethylformamide was treated at 0° C. with 7 mg (0.17 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 50 mg (0.17 mmol) 2-Chloromethyl-6-(4-trifluoromethoxy-phenyl)-pyridine were added and stirred continued at r.t. over night. After addition of 4 ml water, the precipitate was isolated, washed thoroughly with water, n-heptane and diethylether. The residue was dried at 40° C. to give 15 mg (18%) of the title compound as white powder.

出典